# Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Source: https://onco.cc/trials/nct06205485/  
OnCo record `nct06205485` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) and capecitabine in colorectal cancer, run by Canadian Cancer Trials Group, now recruiting.

## Summary

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer is a phase 3, randomised interventional study registered as NCT06205485 by Canadian Cancer Trials Group, with a registry enrolment figure of 250 participants, started 2024-06-26 and due to reach its primary completion in 2030-01-30. Interventions recorded: Leucovorin; Oxaliplatin; Fluoruracil; Capecitabine; Radiation. Conditions listed: Rectal Cancer. Primary outcome: Clinical response rate upon re-staging; Quality of Life defined using the LARS score. Colorectal eligibility wording from the registry: "* Histologically confirmed invasive, well-moderately differentiated rectal adenocarcinoma, mismatch repair proficient". Sites: Canada, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NEO-RT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06205485
- Phase: 3
- Setting: A Phase 3 Randomized Trial Of Neoadjuvant Chemotherapy, Excision And Observation Versus Chemoradiotherapy For Early Rectal Cancer
- Sponsor: Canadian Cancer Trials Group
- Enrolled: 250

## Sources

- ClinicalTrials.gov NCT06205485: https://clinicaltrials.gov/study/NCT06205485

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- companies: [Canadian Cancer Trials Group (CCTG)](https://onco.cc/companies/cctg/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06205485.json