# Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT

Source: https://onco.cc/trials/nct06222489/  
OnCo record `nct06222489` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in lung cancer, run by The Netherlands Cancer Institute, now recruiting.

## Summary

Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT is a phase 2, interventional study registered as NCT06222489 by The Netherlands Cancer Institute, with a registry enrolment figure of 16 participants, started 2025-03-03 and due to reach its primary completion in 2027-05-01. Interventions recorded: 89Zr-Patritumab deruxtecan. Conditions listed: Non-Small Cell Lung Carcinoma; Advanced Non-Small Cell Squamous Lung Cancer; EGFR Gene Mutation. Primary outcome: The optimal imaging dose patritumab deruxtecan to co-inject with 89Zr-Patritumab deruxtecan (HER3-DXd), defined by adequate visualisation of the circulation five days after tracer injection.. Lung eligibility wording from the registry: "Have a histologically or cytologically confirmed diagnosis of (locally) advanced stage EGFR mutation positive NSCLC, not amenable for curative intent treatment". Sites: Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06222489
- Phase: 2
- Setting: Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT
- Sponsor: The Netherlands Cancer Institute
- Enrolled: 16

## Sources

- ClinicalTrials.gov NCT06222489: https://clinicaltrials.gov/study/NCT06222489

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/)
- companies: [Daiichi Sankyo](https://onco.cc/companies/daiichi-sankyo/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06222489.json