# Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients

Source: https://onco.cc/trials/nct06225284/  
OnCo record `nct06225284` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in triple-negative breast cancer, run by National Taiwan University Hospital, now recruiting.

## Summary

Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients is a phase 2, randomised interventional study registered as NCT06225284 by National Taiwan University Hospital, with a registry enrolment figure of 124 participants, started 2024-08-22 and due to reach its primary completion in 2026-12. Interventions recorded: Goserelin Acetate 3.6mg、Goserelin Acetate 10.8mg、Leuprolide Acetate 3.75mg、Leuprorelin Acetate 22.5mg、Triptorelin pamoate 11.25mg、Triptorelin pamoate 22.5mg. Conditions listed: Triple Negative Breast Cancer; Premenopausal Breast Cancer. Triple-negative eligibility wording from the registry: "Histological confirmed TNBC, as defined by the most recent ASCO/CAP guidelines". Sites: Taiwan. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: ESCALATE
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT06225284
- Phase: 2
- Setting: A Randomized Phase II Study of Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients: ESCALATE Study
- Sponsor: National Taiwan University Hospital
- Enrolled: 124

## Sources

- ClinicalTrials.gov NCT06225284: https://clinicaltrials.gov/study/NCT06225284

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06225284.json