# Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct06246344/  
OnCo record `nct06246344` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Adaptive radiotherapy in Rectal cancer, run by Shandong Cancer Hospital and Institute, active and no longer recruiting.

## Summary

Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer is a phase 3 interventional study registered as NCT06246344 by Shandong Cancer Hospital and Institute, with 128 participants planned, started 2023-12-01 and due to reach its primary completion in 2025-12-01. Interventions recorded: Online Adaptive Radiotherapy With Sequential Boost, Conventional Non-Adaptive IMRT, Capecitabine, CAPEOX, Total Mesorectal Excision. Conditions recorded: Rectal Cancer.

Linked to the technology Adaptive radiotherapy because the registry names it ("adaptive radiotherapy") among its interventions and Rectal cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT06246344
- Phase: 3
- Setting: Online Adaptive Radiotherapy With a Boost to the Primary Tumor and Clinically Involved Lymph Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer: A Prospective, Randomized Controlled Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 128

## Sources

- ClinicalTrials.gov NCT06246344: https://clinicaltrials.gov/study/NCT06246344

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Adaptive radiotherapy (online replanning)](https://onco.cc/technologies/adaptive-radiotherapy/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/)

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