# Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

Source: https://onco.cc/trials/nct06248606/  
OnCo record `nct06248606` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of adagrasib in lung cancer, run by Ryan Gentzler, MD, now recruiting.

## Summary

Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases is a phase 2, interventional study registered as NCT06248606 by Ryan Gentzler, MD, with a registry enrolment figure of 30 participants, started 2024-08-06 and due to reach its primary completion in 2027-02-25. Interventions recorded: Adagrasib; Stereotactic Radiosurgery. Conditions listed: Non Small Cell Lung Cancer; NSCLC; KRAS G12C. Primary outcome: Intracranial disease control rate (DCR). Lung eligibility wording from the registry: "Confirmation of stage IV non-small cell lung cancer (NSCLC) per AJCC, 8th edition, or metastatic recurrence after treatment for earlier stage disease". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06248606
- Phase: 2
- Setting: Phase II Study of Adagrasib + Stereotactic Radiosurgery (SRS) for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases
- Sponsor: Ryan Gentzler, MD
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT06248606: https://clinicaltrials.gov/study/NCT06248606

## Connected records

- cancers: [KRAS G12C-mutant non-small-cell lung cancer](https://onco.cc/cancers/kras-g12c-nsclc/)
- technologies: [KRAS & RAS inhibitors](https://onco.cc/technologies/kras-inhibitors/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Adagrasib](https://onco.cc/drugs/adagrasib/)
- companies: [Bristol Myers Squibb](https://onco.cc/companies/bms/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06248606.json