# SAMe in Prevention of Oxaliplatin-associated Liver Injury

Source: https://onco.cc/trials/nct06258525/  
OnCo record `nct06258525` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Cedars-Sinai Medical Center, not yet recruiting.

## Summary

SAMe in Prevention of Oxaliplatin-associated Liver Injury is a phase 2, interventional study registered as NCT06258525 by Cedars-Sinai Medical Center, with a registry enrolment figure of 30 participants, started 2026-07 and due to reach its primary completion in 2028-08. Interventions recorded: Standard of care oxaliplatin-based chemotherapy; S-adenosylmethionine (SAMe) supplement; Surgery. Conditions listed: Colorectal Cancer; Liver Metastases; Liver Metastasis Colon Cancer; Liver Injury; Sinusoidal Obstruction Syndrome; 5-Fluorouracil Toxicity; Liver Toxicity, Chemically-Induced. Primary outcome: To evaluate the efficacy of SAMe in preventing oxaliplatin associated liver injury as determined by lack of injury on histopathologic analysis in patients with liver only stage IV colorectal cancer.. Colorectal eligibility wording from the registry: "* Stage IV patients with resectable liver predominant metastatic colorectal cancer (new diagnosis or recurrent) referred to Cedars Sinai Medical Center for oxaliplatin based systemic therapy". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06258525
- Phase: 2
- Setting: A Phase II, Open-Label Trial of S-Adenosylmethionine (SAMe) in Prevention of Oxaliplatin Associated Liver Injury
- Sponsor: Cedars-Sinai Medical Center
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT06258525: https://clinicaltrials.gov/study/NCT06258525

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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