# DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06275958/  
OnCo record `nct06275958` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Leiden University Medical Center, now recruiting.

## Summary

DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06275958 by Leiden University Medical Center, with a registry enrolment figure of 587 participants, started 2024-07-01 and due to reach its primary completion in 2028-06. Interventions recorded: Doublet Chemotherapy, Standard Dose (100%); Doublet Chemotherapy, Dose-reduced (75%); Monotherapy, Standard Dose (100%); Monotherapy, Dose-reduced (75%). Conditions listed: Older Patients; Colorectal Cancer; Metastatic Cancer; Candidates for Palliative Chemotherapy. Primary outcome: Progression-Free Survival. Colorectal eligibility wording from the registry: "* Patients aged 70 years or older with colorectal cancer and distant metastases without localized treatment options". Sites: Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: DOSAGE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06275958
- Phase: 3
- Setting: DOSAGE Study: a Multicenter Randomized Phase III Trial of DOSe-reduced Chemotherapy for Advanced Colorectal Cancer in Older Patients
- Sponsor: Leiden University Medical Center
- Enrolled: 587

## Sources

- ClinicalTrials.gov NCT06275958: https://clinicaltrials.gov/study/NCT06275958

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06275958.json