# Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

Source: https://onco.cc/trials/nct06300463/  
OnCo record `nct06300463` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of botensilimab and balstilimab in colorectal cancer, run by Weill Medical College of Cornell University, now recruiting.

## Summary

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases is a phase 2, randomised interventional study registered as NCT06300463 by Weill Medical College of Cornell University, with a registry enrolment figure of 24 participants, started 2024-03-26 and due to reach its primary completion in 2026-12. Interventions recorded: Botensilimab; Balstilimab; AGEN1423; Radiation. Conditions listed: Colorectal Cancer Metastatic; Liver Metastases; Colorectal Cancer. Primary outcome: Mean CD8:Treg ratio, as determined by flow cytometry of tumor tissue, at time of surgical resection in each treatment arm. Colorectal eligibility wording from the registry: "* Diagnosis of metastatic colorectal adenocarcinoma with liver metastases". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06300463
- Phase: 2
- Setting: Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases
- Sponsor: Weill Medical College of Cornell University
- Enrolled: 24

## Sources

- ClinicalTrials.gov NCT06300463: https://clinicaltrials.gov/study/NCT06300463

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Balstilimab](https://onco.cc/drugs/balstilimab/), [Botensilimab](https://onco.cc/drugs/botensilimab/)
- companies: [Agenus](https://onco.cc/companies/agenus/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06300463.json