# Open-label, Single Center, Single-arm, Phase 2 Study of Neoadjuvant Pembrolizumab in Combination With Carboplatin and Paclitaxel in Patients With Stage 1 cT1b-T

Source: https://onco.cc/trials/nct06318897/  
OnCo record `nct06318897` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of carboplatin, paclitaxel / nab-paclitaxel, pembrolizumab, doxorubicin and other drugs in triple-negative breast cancer, run by M.D. Anderson Cancer Center, now recruiting.

## Summary

Open-label, Single Center, Single-arm, Phase 2 Study of Neoadjuvant Pembrolizumab in Combination With Carboplatin and Paclitaxel in Patients With Stage 1 cT1b-T1cN0M0 Triple Negative Breast Cancer is a phase 2, randomised interventional study registered as NCT06318897 by M.D. Anderson Cancer Center, with a registry enrolment figure of 28 participants, started 2024-05-29 and due to reach its primary completion in 2027-09-30. Interventions recorded: Carboplatin; Paclitaxel; Pembrolizumab; Doxorubicin; Cyclophosphamide. Conditions listed: Stage 1 cT1b-T1cN0M0; Triple Negative Breast Cancer. Triple-negative eligibility wording from the registry: "Participants must have histologically confirmed ER negative, PR negative and HER2-negative (TNBC) defined as ER\<10%, PR\<10%, and HER2 negative (per 2018 ASCO CAP guidelines)". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT06318897
- Phase: 2
- Setting: Open-label, Single Center, Single-arm, Phase 2 Study of Neoadjuvant Pembrolizumab in Combination With Carboplatin and Paclitaxel in Patients With Stage 1 cT1b-T1cN0M0 Triple Negative Breast Cancer
- Sponsor: M.D. Anderson Cancer Center
- Enrolled: 28

## Sources

- ClinicalTrials.gov NCT06318897: https://clinicaltrials.gov/study/NCT06318897

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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