# Adjuvant Target Therapy Guided by ctDNA-MRD in Patients With EGFR-mutant II-IIIA Non-small Cell Lung Cancer (ECTOP-1022)

Source: https://onco.cc/trials/nct06323148/  
OnCo record `nct06323148` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of osimertinib in lung cancer, run by Fudan University, not yet recruiting.

## Summary

Adjuvant Target Therapy Guided by ctDNA-MRD in Patients With EGFR-mutant II-IIIA Non-small Cell Lung Cancer (ECTOP-1022) is a phase 3, randomised interventional study registered as NCT06323148 by Fudan University, with a registry enrolment figure of 226 participants, started 2024-04-01 and due to reach its primary completion in 2026-03-31. Interventions recorded: Osimertinib; No adjuvant therapy. Conditions listed: Lung Cancer; EGFR Gene Mutation; Minimal Residual Disease. Primary outcome: The 3-year Disease-Free Survival (DFS) rate between the observation group and the osimertinib treatment group.. Lung eligibility wording from the registry: "Histologically confirmed diagnosis of non-small cell lung cancer". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06323148
- Phase: 3
- Setting: Adjuvant Target Therapy Guided by ctDNA-MRD in Patients With EGFR-mutant II-IIIA
- Sponsor: Fudan University
- Enrolled: 226

## Sources

- ClinicalTrials.gov NCT06323148: https://clinicaltrials.gov/study/NCT06323148

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/), [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Osimertinib](https://onco.cc/drugs/osimertinib/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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