# Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery

Source: https://onco.cc/trials/nct06349590/  
OnCo record `nct06349590` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by University of Chicago, now recruiting.

## Summary

Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery is a phase 1/2, interventional study registered as NCT06349590 by University of Chicago, with a registry enrolment figure of 80 participants, started 2024-06-27 and due to reach its primary completion in 2026-04-06. Interventions recorded: High-fiber/low-fat meals. Conditions listed: Colorectal Cancer. Primary outcome: Change in lab values of the dietary intervention on the collagenolytic potential of the microenvironment.. Colorectal eligibility wording from the registry: "* Must have histologically or cytologically confirmed colorectal adenocarcinoma". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: DIET
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06349590
- Phase: 1/2
- Setting: A Phase 1/2 Study of Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery (The DIET Trial)
- Sponsor: University of Chicago
- Enrolled: 80

## Sources

- ClinicalTrials.gov NCT06349590: https://clinicaltrials.gov/study/NCT06349590

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06349590.json