# Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

Source: https://onco.cc/trials/nct06353386/  
OnCo record `nct06353386` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Opevesostat, Olaparib, Docetaxel, Cabazitaxel, Dexamethasone and Prednisone in prostate cancer, run by Merck Sharp & Dohme LLC, now recruiting.

## Summary

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A) is a phase 1/2 interventional study registered as NCT06353386 by Merck Sharp & Dohme LLC, with 220 participants planned, started 2024-05-20 and due to reach its primary completion in 2029-01-15. Interventions recorded: Opevesostat, Olaparib, Docetaxel, Cabazitaxel, Fludrocortisone acetate and Dexamethasone.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT06353386
- Phase: 1/2
- Setting: MK-5684-01A Substudy: A Phase 1/2 Umbrella Substudy of MK-5684-U01 Master Protocol to Evaluate the Safety and Efficacy of MK-5684-based Treatment Combinations or MK-5684 Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)
- Sponsor: Merck Sharp & Dohme LLC
- Enrolled: 220

## Sources

- ClinicalTrials.gov NCT06353386: https://clinicaltrials.gov/study/NCT06353386

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- drugs: [Cabazitaxel](https://onco.cc/drugs/cabazitaxel/), [Dexamethasone](https://onco.cc/drugs/dexamethasone/), [Docetaxel](https://onco.cc/drugs/docetaxel/), [Olaparib](https://onco.cc/drugs/olaparib/), [Opevesostat](https://onco.cc/drugs/opevesostat/), [Prednisone](https://onco.cc/drugs/prednisone/)
- companies: [Merck & Co. (MSD)](https://onco.cc/companies/merck/)

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