# Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases

Source: https://onco.cc/trials/nct06356584/  
OnCo record `nct06356584` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases is a phase 2, randomised interventional study registered as NCT06356584 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 62 participants, started 2024-04-01 and due to reach its primary completion in 2026-10-01. Interventions recorded: Immunotherapy (Sintilimab); Targeted Therapy Agent (Fruquintinib); Radiotherapy (SBRT and LDRT). Conditions listed: Colorectal Cancer; Immunotherapy; Radiotherapy; Targeted Therapy; Liver Metastasis. Primary outcome: Progression-free survival (PFS). Colorectal eligibility wording from the registry: "* Histologically confirmed colorectal adenocarcinoma with liver metastases (8th edition AJCC)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06356584
- Phase: 2
- Setting: Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases: A Randomized, Controlled, Multicenter Phase II Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 62

## Sources

- ClinicalTrials.gov NCT06356584: https://clinicaltrials.gov/study/NCT06356584

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06356584.json