# A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

Source: https://onco.cc/trials/nct06380816/  
OnCo record `nct06380816` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in triple-negative breast cancer, run by Cancer Research UK, now recruiting.

## Summary

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer is a phase 1/2, interventional study registered as NCT06380816 by Cancer Research UK, with a registry enrolment figure of 167 participants, started 2024-07-09 and due to reach its primary completion in 2029-11. Interventions recorded: UCB4594. Conditions listed: Advanced Solid Tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Renal Cell (Clear Cell Only); Esophageal Neoplasms; Stomach Neoplasms (Excluding Gastrointestinal Stromal Tumors); Uterine Cervical Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms. Triple-negative eligibility wording from the registry: "Module A (dose escalation): Tumour types which have shown high levels of human HLA-G expression (as reported in the literature): head and neck squamous cell carcinoma, non-small cell lung cancer, colorectal cancer, triple-negative breast cancer, renal cell cancer (clear cell only), oesophago-gastric". Sites: United Kingdom. United Kingdom sites listed: 4. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT06380816
- Phase: 1/2
- Setting: A Cancer Research UK Phase I/II Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of UCB4594 Alone and in Combination With Anti-cancer Treatments in Participants With Advanced Malignancies
- Sponsor: Cancer Research UK
- Enrolled: 167

## Notes

- UK sites (registry): Guy's Hopsital (London); The Christie NHS Foundation Trust (Manchester); The Newcastle upon Tyne Hospitals NHS Foundation Trust (Newcastle upon Tyne); University Hospital Southampton NHS Foundation Trust (Southampton).

## Sources

- ClinicalTrials.gov NCT06380816: https://clinicaltrials.gov/study/NCT06380816

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06380816.json