# To Evaluate the Efficacy and Safety of Disitamab Vedotin Combined With Toripalimab Sequential Chemotherapy as Neoadjuvant Treatment in Patients With HR-positive, HER2-low Breast Cancer

Source: https://onco.cc/trials/nct06389006/  
OnCo record `nct06389006` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Disitamab vedotin, Toripalimab, Epirubicin and Cyclophosphamide in HER2-positive breast cancer and HR-positive / HER2-negative breast cancer, run by RemeGen Co., Ltd., now recruiting.

## Summary

To Evaluate the Efficacy and Safety of Disitamab Vedotin Combined With Toripalimab Sequential Chemotherapy as Neoadjuvant Treatment in Patients With HR-positive, HER2-low Breast Cancer is a phase 2 interventional study registered as NCT06389006 by RemeGen Co., Ltd., with 79 participants planned, started 2024-04-29 and due to reach its primary completion in 2025-06-01. Interventions recorded: Disitamab Vedotin for Injection, Toripalimab, Epirubicin and Cyclophosphamide.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT06389006
- Phase: 2
- Setting: A Single-arm, Open-label, Multicenter Phase II Clinical Trial to Evaluate the Efficacy and Safety of Disitamab Vedotin Combined With Toripalimab Sequential Chemotherapy as Neoadjuvant Treatment in Patients With HR-positive, HER2-low Breast Cancer
- Sponsor: RemeGen Co., Ltd.
- Enrolled: 79

## Sources

- ClinicalTrials.gov NCT06389006: https://clinicaltrials.gov/study/NCT06389006

## Connected records

- cancers: [HER2-positive breast cancer](https://onco.cc/cancers/breast-her2-positive/), [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- drugs: [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Disitamab vedotin](https://onco.cc/drugs/disitamab-vedotin/), [Epirubicin](https://onco.cc/drugs/epirubicin/), [Toripalimab](https://onco.cc/drugs/toripalimab/)
- companies: [RemeGen](https://onco.cc/companies/remegen/)

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