# Combination Therapy for BRAF-V600E Metastatic CRCm

Source: https://onco.cc/trials/nct06411600/  
OnCo record `nct06411600` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of encorafenib, cetuximab and bevacizumab (glioblastoma use) in colorectal cancer, run by Vall d'Hebron Institute of Oncology, now recruiting.

## Summary

Combination Therapy for BRAF-V600E Metastatic CRCm is a phase 2, interventional study registered as NCT06411600 by Vall d'Hebron Institute of Oncology, with a registry enrolment figure of 94 participants, started 2024-05-17 and due to reach its primary completion in 2027-05-01. Interventions recorded: Encorafenib; Cetuximab; Bevacizumab. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Progression-Free Survival (PFS). Colorectal eligibility wording from the registry: "5 x ULN is allowed if direct (conjugated) ≤1". Sites: Spain. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: BRAVE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06411600
- Phase: 2
- Setting: Bevacizumab Plus encoRAfenib-cetuximab in BRAF-V600E Mutated Metastatic Colorectal Cancer, a Phase II Study With a Safety lead-in Cohort, the BRAVE Trial
- Sponsor: Vall d'Hebron Institute of Oncology
- Enrolled: 94

## Sources

- ClinicalTrials.gov NCT06411600: https://clinicaltrials.gov/study/NCT06411600

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Monoclonal antibodies](https://onco.cc/technologies/monoclonal-antibody/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Cetuximab](https://onco.cc/drugs/cetuximab/), [Encorafenib](https://onco.cc/drugs/encorafenib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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