# Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy

Source: https://onco.cc/trials/nct06411795/  
OnCo record `nct06411795` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in pancreatic cancer, run by Masonic Cancer Center, University of Minnesota, now recruiting.

## Summary

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy is a phase 2, randomised interventional study registered as NCT06411795 by Masonic Cancer Center, University of Minnesota, with a registry enrolment figure of 78 participants, started 2023-11-10 and due to reach its primary completion in 2027-01-01. Interventions recorded: Bupivacaine; Hydromorphone; Iopamidol; Liposomal Bupivacaine; Medical Chart Review; Questionnaire Administration; Thoracic Epidural Analgesia; Ultrasound Imaging; X-Ray Imaging. Conditions listed: Duodenal Neoplasm; Pancreatic Neoplasm. Primary outcome: Milligram morphine equivalents (MME). Pancreatic eligibility wording from the registry: "* Adult patients, age 18 and older, undergoing open pancreaticoduodenectomy at the University of Minnesota will be included in the study". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06411795
- Phase: 2
- Setting: Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy: A Prospective, Randomized, Non-Inferiority Trial
- Sponsor: Masonic Cancer Center, University of Minnesota
- Enrolled: 78

## Sources

- ClinicalTrials.gov NCT06411795: https://clinicaltrials.gov/study/NCT06411795

## Connected records

- cancers: [Resectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/resectable-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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