# JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation

Source: https://onco.cc/trials/nct06416410/  
OnCo record `nct06416410` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing Sitneprotafib in non-small-cell lung cancer, now recruiting.

## Summary

JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation is a phase 3 interventional study registered as NCT06416410, led by Allist Pharmaceuticals, and recruiting on the registry. Official title: An Open-label, Randomised, Positive Control, Multicenter Phase III Clinical Study. Evaluating JAB-21822 Combined With JAB-3312 Compared Tislelizumab Combined With Pemetrexed + Carboplatin in the First Line for Treatment of Advanced Non-squamous Non-small Cell Lung Cancer With KRAS p.G12C Mutation. Planned enrolment is 392 participants (estimated). The study started in 2024-08-07 and primary completion is expected in 2029-09-30. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Tags: ctgov-ingest
- Registry id: NCT06416410
- Phase: 3
- Setting: An Open-label, Randomized, Positive Control, Multicenter Phase III Clinical Study. Evaluating JAB-21822 Combined With JAB-3312 Compared Tislelizumab Combined With Pemetrexed + Carboplatin in the First Line for Treatment of Advanced Non-squamous Non-small Cell Lung Cancer With KRAS p.G12C Mutation
- Sponsor: Allist Pharmaceuticals
- Enrolled: 392

## Sources

- ClinicalTrials.gov NCT06416410: https://clinicaltrials.gov/study/NCT06416410

## Connected records

- cancers: [KRAS G12C-mutant non-small-cell lung cancer](https://onco.cc/cancers/kras-g12c-nsclc/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Glecirasib](https://onco.cc/drugs/glecirasib/), [Sitneprotafib](https://onco.cc/drugs/sitneprotafib/)
- companies: [Shanghai Allist Pharmaceuticals](https://onco.cc/companies/allist/)

---
JSON: https://onco.cc/api/v1/entities/nct06416410.json