# Exploratory Clinical Study of HRS-4642 Combined With Adebrelimab in the Treatment of Advanced Pancreatic Ductal Adenocarcinoma

Source: https://onco.cc/trials/nct06427239/  
OnCo record `nct06427239` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of adebrelimab and SHR-8068 in pancreatic cancer, run by Fudan University, now recruiting.

## Summary

Exploratory Clinical Study of HRS-4642 Combined With Adebrelimab in the Treatment of Advanced Pancreatic Ductal Adenocarcinoma is a phase 1/2, interventional study registered as NCT06427239 by Fudan University, with a registry enrolment figure of 130 participants, started 2024-06-17 and due to reach its primary completion in 2027-06. Interventions recorded: HRS-4642; Adebrelimab; SHR-8068; Faminitib or bevacizumab. Conditions listed: Pancreatic Cancer. Primary outcome: Dose Limited Toxicity (DLT); Recommended phase II dose (RP2D); Objective Response Rate (ORR). Pancreatic eligibility wording from the registry: "Advanced (metastatic or unresectable) Pancreatic ductal adenocarcinoma; and subjects must have at least one measurable lesion as defined by RECIST v1". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06427239
- Phase: 1/2
- Setting: A Single-center, Open-label, Exploratory Study of HRS-4642 Combined With Adebrelimab, or With Adebrelimab and Other Antitumor Agents in the Treatment of Advanced Pancreatic Ductal Adenocarcinoma
- Sponsor: Fudan University
- Enrolled: 130

## Sources

- ClinicalTrials.gov NCT06427239: https://clinicaltrials.gov/study/NCT06427239

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Adebrelimab](https://onco.cc/drugs/adebrelimab/), [SHR-8068](https://onco.cc/drugs/shr-8068/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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