# A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Source: https://onco.cc/trials/nct06428409/  
OnCo record `nct06428409` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Sacituzumab tirumotecan, Fluorouracil, FLOT in colorectal cancer and pancreatic ductal adenocarcinoma, run by Merck Sharp & Dohme LLC, now recruiting.

## Summary

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A) is a phase 1/2 interventional study registered as NCT06428409 by Merck Sharp & Dohme LLC, with 220 participants planned, started 2024-06-20 and due to reach its primary completion in 2029-10-16. Interventions recorded: Sacituzumab tirumotecan, Fluorouracil (5-FU), Leucovorin (LV) or levoleucovorin, Rescue medication, Supportive care measures. Conditions listed: Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06428409
- Phase: 1/2
- Setting: A Phase 1/2 Study to Evaluate the Safety and Efficacy of MK-2870 Monotherapy or in Combination With Other Anticancer Agents in Gastrointestinal Cancers
- Sponsor: Merck Sharp & Dohme LLC
- Enrolled: 220

## Sources

- ClinicalTrials.gov NCT06428409: https://clinicaltrials.gov/study/NCT06428409

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- drugs: [Cisplatin](https://onco.cc/drugs/cisplatin/), [FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)](https://onco.cc/drugs/flot/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Sacituzumab tirumotecan](https://onco.cc/drugs/sacituzumab-tirumotecan/)
- companies: [Merck & Co. (MSD)](https://onco.cc/companies/merck/)

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JSON: https://onco.cc/api/v1/entities/nct06428409.json