# Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.

Source: https://onco.cc/trials/nct06431633/  
OnCo record `nct06431633` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of zimberelimab, sacituzumab govitecan, cisplatin and carboplatin in lung cancer, run by Fundación GECP, now recruiting.

## Summary

Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free. is a phase 3, randomised interventional study registered as NCT06431633 by Fundación GECP, with a registry enrolment figure of 129 participants, started 2025-02-04 and due to reach its primary completion in 2031-11-30. Interventions recorded: Zimberelimab; Sacituzumab govitecan; Cisplatin; Carboplatin. Conditions listed: Lung Diseases; Carcinoma, Non-Small-Cell Lung; Resectable Lung Non-Small Cell Carcinoma. Primary outcome: Disease free survival. Lung eligibility wording from the registry: "Patients diagnosed of primary non-small cell lung cancer, histologically confirmed". Sites: Spain. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: ARIAN
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06431633
- Phase: 3
- Setting: A Phase III Clinical Trial of Adjuvant Treatment With Sacituzumab and Zimberelimab for Stage IB-IIIA-IIIB(N2) Previously Resected (R0) Non-small Cell Lung Cancer Patients That Did Not Achieve Pathological Complete Response After Neoadjuvant treatment_ARIAN
- Sponsor: Fundación GECP
- Enrolled: 129

## Sources

- ClinicalTrials.gov NCT06431633: https://clinicaltrials.gov/study/NCT06431633

## Connected records

- cancers: [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/), [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Sacituzumab govitecan](https://onco.cc/drugs/sacituzumab-govitecan/), [Zimberelimab](https://onco.cc/drugs/zimberelimab/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06431633.json