# De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unrese

Source: https://onco.cc/trials/nct06446557/  
OnCo record `nct06446557` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by University Hospital, Rouen, not yet recruiting.

## Summary

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06446557 by University Hospital, Rouen, with a registry enrolment figure of 408 participants, started 2026-06 and due to reach its primary completion in 2032-06-01. Interventions recorded: treatment adaptation guided by ctDNA variation; standard management. Conditions listed: Metastatic Colon Cancer. Primary outcome: Evaluate the superiority in quality-adjusted OS of an early treatment adaptation guided by ctDNA variation. Colorectal eligibility wording from the registry: "* Histologically proven diagnosis of RAS WT or mutant, MSS, BRAFV600E non-mutated colorectal cancer". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: DIAMOND
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06446557
- Phase: 3
- Setting: De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND Study): A Randomized Phase III of PRODIGE Intergroup
- Sponsor: University Hospital, Rouen
- Enrolled: 408

## Sources

- ClinicalTrials.gov NCT06446557: https://clinicaltrials.gov/study/NCT06446557

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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