# Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)

Source: https://onco.cc/trials/nct06450574/  
OnCo record `nct06450574` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of capecitabine in colorectal cancer, run by Corporacion Parc Tauli, not yet recruiting.

## Summary

Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study) is a phase 3, randomised interventional study registered as NCT06450574 by Corporacion Parc Tauli, with a registry enrolment figure of 106 participants, started 2024-10 and due to reach its primary completion in 2026-10. Interventions recorded: Capecitabine (Xeloda); 50.4 Gy; Transanal Endoscopic Microsurgery (TEM); Transanal Endoscopic Microsurgery. Conditions listed: Rectal Cancer Stage I. Primary outcome: Rectal preservation in T1,N0,M0 rectal cancer; Total mesorectal excision in T1,N0,M0 rectal cancer. Colorectal eligibility wording from the registry: "* Rectal adenocarcinomas in the biopsy, located at a distance from the anal margin less than or equal to 10 cm measured by rigid rectoscopy at the time of ER". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: TAUTEM-T1
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06450574
- Phase: 3
- Setting: Prospective, Controlled and Randomized Phase III Multicentric Study of the Treatment of T1,N0,M0 Rectal Cancer. Neoadjuvant Therapy and Transanal Endoscopic Surgery vs. Transanal Endoscopic Surgery (TAUTEM-T1 Study)
- Sponsor: Corporacion Parc Tauli
- Enrolled: 106

## Sources

- ClinicalTrials.gov NCT06450574: https://clinicaltrials.gov/study/NCT06450574

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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