# A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-sma

Source: https://onco.cc/trials/nct06452277/  
OnCo record `nct06452277` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Sevabertinib, Pembrolizumab, Cisplatin in non-small-cell lung cancer and small-cell lung cancer, run by Bayer, now recruiting.

## Summary

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) is a phase 3 interventional study registered as NCT06452277 by Bayer, with 444 participants planned, started 2024-08-28 and due to reach its primary completion in 2027-10-28. Interventions recorded: Sevabertinib, Pembrolizumab, Cisplatin, Carboplatin, Pemetrexed. Conditions listed: Advanced Non-small Cell Lung Cancer, HER2 Mutation. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06452277
- Phase: 3
- Setting: A Phase 3 Open-label, Randomized, Active-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Orally Administered BAY 2927088 Compared With Standard of Care as a First-line Therapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With HER2-activating Mutations
- Sponsor: Bayer
- Enrolled: 444

## Sources

- ClinicalTrials.gov NCT06452277: https://clinicaltrials.gov/study/NCT06452277

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Pemetrexed](https://onco.cc/drugs/pemetrexed/), [Sevabertinib](https://onco.cc/drugs/sevabertinib/)
- companies: [Bayer](https://onco.cc/companies/bayer/)

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JSON: https://onco.cc/api/v1/entities/nct06452277.json