# A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment

Source: https://onco.cc/trials/nct06453486/  
OnCo record `nct06453486` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in pancreatic cancer, run by University Health Network, Toronto, now recruiting.

## Summary

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment is a phase 2, interventional study registered as NCT06453486 by University Health Network, Toronto, with a registry enrolment figure of 43 participants, started 2025-03-12 and due to reach its primary completion in 2030-04. Interventions recorded: High dose radiation therapy. Conditions listed: Locally Advanced Pancreatic Adenocarcinoma. Primary outcome: Overall survival (OS). Pancreatic eligibility wording from the registry: "* Have pancreatic tumour \<8". Sites: Canada. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: ABLATE
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06453486
- Phase: 2
- Setting: Ablative Radiation Therapy With High Dose Geometric Boost for Locally Advanced Pancreatic Cancer Patients Following Treatment Response Evaluation of Standard of Care Induction Chemotherapy (ABLATE): a Phase II Clinical Trial
- Sponsor: University Health Network, Toronto
- Enrolled: 43

## Sources

- ClinicalTrials.gov NCT06453486: https://clinicaltrials.gov/study/NCT06453486

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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