# SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC

Source: https://onco.cc/trials/nct06457906/  
OnCo record `nct06457906` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, now recruiting.

## Summary

SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC is a phase 3, randomised interventional study registered as NCT06457906 by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, with a registry enrolment figure of 340 participants, started 2023-09-01 and due to reach its primary completion in 2027-08-30. Interventions recorded: Experimental group (SRS/SRT/Hypo-RT); Controled group (HA-WBRT). Conditions listed: Small-cell Lung Cancer; Brain Metastases; SRS; Stereotactic Radiotherapy; Whole Brain Radiotherpay; Hippocampal-avoidance. Primary outcome: Cognitive function scores; Meadian OS time. Lung eligibility wording from the registry: "Pathologically (histologically or cytologically) proven diagnosis of small cell lung cancer within 5 years of registration". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: SHARP
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06457906
- Phase: 3
- Setting: SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in Patients With Small-Cell Lung Cancer: A Prospective, Randomized, Multicenter Phase III Trial (SHARP Trial)
- Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Enrolled: 340

## Sources

- ClinicalTrials.gov NCT06457906: https://clinicaltrials.gov/study/NCT06457906

## Connected records

- cancers: [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06457906.json