# Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Source: https://onco.cc/trials/nct06500455/  
OnCo record `nct06500455` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by NRG Oncology, active but no longer recruiting.

## Summary

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain is a phase 3, randomised interventional study registered as NCT06500455 by NRG Oncology, with a registry enrolment figure of 274 participants, started 2024-12-12 and due to reach its primary completion in 2028-06-30. Interventions recorded: Computed Tomography; Fractionated Stereotactic Radiation Therapy; Magnetic Resonance Imaging; Stereotactic Radiosurgery. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Digestive System Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Solid Neoplasm; Metastatic Melanom. Primary outcome: Time to local failure. Lung eligibility wording from the registry: "* Non-small cell lung cancer". Sites: Canada, Hong Kong, Ireland, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06500455
- Phase: 3
- Setting: Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
- Sponsor: NRG Oncology
- Enrolled: 274

## Sources

- ClinicalTrials.gov NCT06500455: https://clinicaltrials.gov/study/NCT06500455

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06500455.json