# Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Source: https://onco.cc/trials/nct06500481/  
OnCo record `nct06500481` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by NRG Oncology, now recruiting.

## Summary

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial is a phase 3, randomised interventional study registered as NCT06500481 by NRG Oncology, with a registry enrolment figure of 115 participants, started 2025-03-04 and due to reach its primary completion in 2028-07-31. Interventions recorded: Biospecimen Collection; Computed Tomography; Involved-Field Radiation Therapy; Lumbar Puncture; Magnetic Resonance Imaging; Positron Emission Tomography; Proton Beam Craniospinal Irradiation; Quality-of-Life Assessment. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Leptomeninges; Stage IV Lung Cancer AJCC v8. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: "* Patients with pathologically (histologically or cytologically) proven diagnosis of breast cancer or NSCLC". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06500481
- Phase: 3
- Setting: A Phase III Randomized Clinical Trial of Proton Craniospinal Irradiation Versus Involved-Field Radiotherapy for Patients With Breast Cancer or Non-Small Cell Lung Cancer Leptomeningeal Metastasis (Radiate-LM)
- Sponsor: NRG Oncology
- Enrolled: 115

## Sources

- ClinicalTrials.gov NCT06500481: https://clinicaltrials.gov/study/NCT06500481

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Proton therapy](https://onco.cc/technologies/proton-therapy/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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