# 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Source: https://onco.cc/trials/nct06503146/  
OnCo record `nct06503146` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in pancreatic cancer, run by National Cancer Institute (NCI), now recruiting.

## Summary

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection is a phase 2, interventional study registered as NCT06503146 by National Cancer Institute (NCI), with a registry enrolment figure of 320 participants, started 2025-09-09 and due to reach its primary completion in 2028-06-01. Interventions recorded: [18F]FAPI-74; [18F]FDG. Conditions listed: Sarcoma; Small Cell Lung Cancer or Extrapulmonary Neuroendocrine Cancer (EP-NEC); Mesothelioma; Pheochromocytoma/Paraganglioma (PPGL); Pancreatic Ductal Adenocarcinoma; Ovarian Cancer; Hepatocellular Carcinoma; Gastric Cancer; Cholangiocarcinoma; Bladder Cancer. Primary outcome: Mean number of lesions. Pancreatic eligibility wording from the registry: "* Histologically confirmed pancreatic ductal adenocarcinoma (PDAC), cholangiocarcinoma, hepatocellular carcinoma (HCC), gastric cancer, bladder cancer, ovarian cancer, pheochromocytoma/paraganglioma (PPGL), small cell lung cancer (SCLC) or extrapulmonary neuroendocrine cancer (EP-NEC), mesothelioma ". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06503146
- Phase: 2
- Setting: 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
- Sponsor: National Cancer Institute (NCI)
- Enrolled: 320

## Sources

- ClinicalTrials.gov NCT06503146: https://clinicaltrials.gov/study/NCT06503146

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06503146.json