# Intermittent or Continuous Panitumumab Plus FOLFIRI for Left Sided RAS/B-RAF Wild-type Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06509126/  
OnCo record `nct06509126` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of panitumumab, fOLFIRI (5-FU, leucovorin, irinotecan) and fluorouracil (5-FU) in colorectal cancer, run by National Cancer Institute, Naples, now recruiting.

## Summary

Intermittent or Continuous Panitumumab Plus FOLFIRI for Left Sided RAS/B-RAF Wild-type Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06509126 by National Cancer Institute, Naples, with a registry enrolment figure of 500 participants, started 2024-06-12 and due to reach its primary completion in 2028-01. Interventions recorded: Panitumumab; Irinotecan; 5-fluorouracil; L-folinic acid. Conditions listed: Colorectal Cancer Stage IV. Primary outcome: Time to Treatment Failure. Sites: Italy. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: IMPROVE-2
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06509126
- Phase: 3
- Setting: Randomized Phase 3 Study of Intermittent or Continuous Panitumumab Plus FOLFIRI for First-line Treatment of Patients With Unresectable Left Sided RAS/B-RAF Wild-type Metastatic Colorectal Cancer (IMPROVE-2 Trial)
- Sponsor: National Cancer Institute, Naples
- Enrolled: 500

## Sources

- ClinicalTrials.gov NCT06509126: https://clinicaltrials.gov/study/NCT06509126

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Monoclonal antibodies](https://onco.cc/technologies/monoclonal-antibody/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [Panitumumab](https://onco.cc/drugs/panitumumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06509126.json