# Adjuvant PD-1 Blockade for High-risk Stage-II DMMR/MSI-H Colorectal Cancer

Source: https://onco.cc/trials/nct06520683/  
OnCo record `nct06520683` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of tislelizumab in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Adjuvant PD-1 Blockade for High-risk Stage-II DMMR/MSI-H Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06520683 by Sun Yat-sen University, with a registry enrolment figure of 180 participants, started 2024-11-01 and due to reach its primary completion in 2027-11-01. Interventions recorded: Tislelizumab; Adjuvant chemotherapy. Conditions listed: Colorectal Cancer; Microsatellite Instability High. Primary outcome: Disease-free survival (DFS). Colorectal eligibility wording from the registry: "* dMMR and/or MSI-H colorectal carcinoma that undergo surgical resection". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: SMALLER
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06520683
- Phase: 3
- Setting: Short-course PD-1 Blockade As Adjuvant Treatment for High-risk Stage-II DMMR/MSI-H Colorectal Cancer
- Sponsor: Sun Yat-sen University
- Enrolled: 180

## Sources

- ClinicalTrials.gov NCT06520683: https://clinicaltrials.gov/study/NCT06520683

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Tislelizumab](https://onco.cc/drugs/tislelizumab/)
- companies: [BeOne Medicines (formerly BeiGene)](https://onco.cc/companies/beone/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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