# Phase II Study of Serplulimab Combined with First-Line Targeted Therapy, Chemotherapy, and Radiation in Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct06521866/  
OnCo record `nct06521866` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of serplulimab in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Phase II Study of Serplulimab Combined with First-Line Targeted Therapy, Chemotherapy, and Radiation in Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT06521866 by Fudan University, with a registry enrolment figure of 208 participants, started 2025-03-01 and due to reach its primary completion in 2026-08-01. Interventions recorded: Serplulimab; Chemotherapy; SABR; Targeted therapy. Conditions listed: Advanced Colorectal Carcinoma; Immunotherapy. Primary outcome: PFS. Colorectal eligibility wording from the registry: "Histologically confirmed metastatic colorectal cancer (Stage IV, UICC), with initially unresectable metastases or refusal of surgery;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06521866
- Phase: 2
- Setting: A Prospective, Randomized, Phase II, Multicenter Clinical Study of Serplulimab Combined with First-Line Targeted Therapy and Chemotherapy with or Without Radiation in the First-Line Treatment of Advanced Colorectal Cancer
- Sponsor: Fudan University
- Enrolled: 208

## Sources

- ClinicalTrials.gov NCT06521866: https://clinicaltrials.gov/study/NCT06521866

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Serplulimab](https://onco.cc/drugs/serplulimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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