# Standard Systemic Therapy Combined With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06525428/  
OnCo record `nct06525428` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of toripalimab in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Standard Systemic Therapy Combined With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06525428 by Fudan University, with a registry enrolment figure of 96 participants, started 2024-04-01 and due to reach its primary completion in 2026-12. Interventions recorded: standard systemic therapy combined with high/low-dose radiotherapy plus toripalimab. Conditions listed: Microsatellite Stable Metastatic Colorectal Cancer. Primary outcome: PFS. Colorectal eligibility wording from the registry: "Histopathological confirmed MSS/pMMR adenocarcinoma of the colon or rectum". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06525428
- Phase: 2
- Setting: A Prospective, Two-cohort Phase II Trial of Standard Systemic Therapy in Combination With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer
- Sponsor: Fudan University
- Enrolled: 96

## Sources

- ClinicalTrials.gov NCT06525428: https://clinicaltrials.gov/study/NCT06525428

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Toripalimab](https://onco.cc/drugs/toripalimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06525428.json