# Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer

Source: https://onco.cc/trials/nct06530303/  
OnCo record `nct06530303` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of cyclophosphamide, fludarabine, aldesleukin (high-dose IL-2) and pembrolizumab in colorectal cancer, run by Essen Biotech, now recruiting.

## Summary

Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer is a phase 1/2, interventional study registered as NCT06530303 by Essen Biotech, with a registry enrolment figure of 85 participants, started 2024-09-29 and due to reach its primary completion in 2026-09-10. Interventions recorded: Tumor Infiltrating Lymphocytes (TIL); Cyclophosphamide; Fludarabine; Interleukin-2; Pembrolizumab. Conditions listed: Colorectal Cancer; Colon Cancer; Rectum Cancer. Primary outcome: Adverse Events. Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: BAH248
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06530303
- Phase: 1/2
- Setting: Efficacy and Safety of Autologous Tumor-Infiltrating Lymphocytes (TIL) Therapy Combined With Immunotherapy in Patients With Advanced or Metastatic Refractory Colon and Rectal Cancer (Colorectum)
- Sponsor: Essen Biotech
- Enrolled: 85

## Sources

- ClinicalTrials.gov NCT06530303: https://clinicaltrials.gov/study/NCT06530303

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Aldesleukin (high-dose IL-2)](https://onco.cc/drugs/aldesleukin/), [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Fludarabine](https://onco.cc/drugs/fludarabine/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06530303.json