# Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARC

Source: https://onco.cc/trials/nct06542588/  
OnCo record `nct06542588` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of serplulimab in colorectal cancer, run by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, now recruiting.

## Summary

Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARC is a phase 2, interventional study registered as NCT06542588 by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, with a registry enrolment figure of 29 participants, started 2024-07-19 and due to reach its primary completion in 2025-12. Interventions recorded: HLX07(anti EGFR antibody) and Serplulimab(anti PD-1 antibody). Conditions listed: Rectal Cancer. Primary outcome: complete response (CR) rate. Colorectal eligibility wording from the registry: "Histologically confirmed Locally Advanced rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06542588
- Phase: 2
- Setting: A Multicenter, Single-arm, Open-label Clinical Trial of Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07 and Serplulimab in the Treatment for RAS/BRAF Wild Type Locally Advanced Rectal Cancer
- Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Enrolled: 29

## Sources

- ClinicalTrials.gov NCT06542588: https://clinicaltrials.gov/study/NCT06542588

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Serplulimab](https://onco.cc/drugs/serplulimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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