# Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI

Source: https://onco.cc/trials/nct06545747/  
OnCo record `nct06545747` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI is a phase 3, randomised interventional study registered as NCT06545747 by Sun Yat-sen University, with a registry enrolment figure of 490 participants, started 2024-08-01 and due to reach its primary completion in 2028-07-31. Interventions recorded: DCE-MRI based split-course hypo-RT; CT based split-course hypo-RT; Concurrent chemotherapy; Consolidative immunotherapy. Conditions listed: Non-small Cell Lung Cancer. Primary outcome: treatment-related G2+ respiratory toxicity; progression-free survival rate. Lung eligibility wording from the registry: "* Patients must have histological or cytological confirmation of locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06545747
- Phase: 3
- Setting: A Randomized Controlled Phase III Study of Adaptive Hypofractionated Radiotherapy Combined With Concurrent Chemotherapy and Consolidative Immunotherapy in Locally Advanced Non-Small Cell Lung Cancer Based on Dynamic Enhanced Magnetic Resonance Imaging
- Sponsor: Sun Yat-sen University
- Enrolled: 490

## Sources

- ClinicalTrials.gov NCT06545747: https://clinicaltrials.gov/study/NCT06545747

## Connected records

- cancers: [Unresectable stage III non-small-cell lung cancer](https://onco.cc/cancers/stage-iii-unresectable-nsclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06545747.json