# An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis

Source: https://onco.cc/trials/nct06557733/  
OnCo record `nct06557733` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by National Cancer Institute (NCI), now recruiting.

## Summary

An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis is a phase 2, interventional study registered as NCT06557733 by National Cancer Institute (NCI), with a registry enrolment figure of 38 participants, started 2026-03-31 and due to reach its primary completion in 2027-06-30. Interventions recorded: Biopsy Procedure; Biospecimen Collection; EP2/EP4 Antagonist TPST-1495; Esophagogastroduodenoscopy; Gastrointestinal Endoscopy; Questionnaire Administration. Conditions listed: Colorectal Carcinoma; Familial Adenomatous Polyposis. Primary outcome: Percent change in duodenal polyp burden; Incidence of adverse events. Colorectal eligibility wording from the registry: "* Clinical diagnosis of classic FAP with ≥ 100 colorectal adenomas status post colectomy or a sub-total colectomy and a family history of FAP". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06557733
- Phase: 2
- Setting: Phase 2 Study to Evaluate the Efficacy and Safety of TPST-1495 in Patients With Familial Adenomatous Polyposis (FAP)
- Sponsor: National Cancer Institute (NCI)
- Enrolled: 38

## Sources

- ClinicalTrials.gov NCT06557733: https://clinicaltrials.gov/study/NCT06557733

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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