# OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial

Source: https://onco.cc/trials/nct06558214/  
OnCo record `nct06558214` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Laser interstitial thermal therapy systems in Glioma & glioblastoma, run by University of Florida, now recruiting.

## Summary

OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial is a phase 2 interventional study registered as NCT06558214 by University of Florida, with 20 participants planned, started 2024-12-10 and due to reach its primary completion in 2029-10. Interventions recorded: Pembrolizumab, Optune GIO®, NeuroBlate®. Conditions recorded: Recurrent Glioblastoma.

Linked to the technology Laser interstitial thermal therapy systems because the registry names it ("neuroblate") among its interventions and Glioma & glioblastoma among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT06558214
- Phase: 2
- Setting: OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial
- Sponsor: University of Florida
- Enrolled: 20

## Sources

- ClinicalTrials.gov NCT06558214: https://clinicaltrials.gov/study/NCT06558214

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)
- technologies: [Laser interstitial thermal therapy systems (NeuroBlate, Visualase)](https://onco.cc/technologies/litt-systems/)
- drugs: [Optune / Optune Pax (TTFields)](https://onco.cc/drugs/optune/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)

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