# FTD-TPI, Bevacizumab, and Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06563986/  
OnCo record `nct06563986` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by UMC Utrecht, now recruiting.

## Summary

FTD-TPI, Bevacizumab, and Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06563986 by UMC Utrecht, with a registry enrolment figure of 40 participants, started 2024-06-18 and due to reach its primary completion in 2028-01. Interventions recorded: Systemic treatment (FTD-TPI and bevacizumab); Radioembolization with 166-Ho microspheres. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Hepatic objective response rate (hORR) (PERCIST 1.0). Colorectal eligibility wording from the registry: "* Prior therapy with fluoropyrimidine, oxaliplatin, and irinotecan for the treatment of metastatic colorectal cancer and had demonstrated progressive disease or intolerance to their last regimen". Sites: Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: STARLIGHT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06563986
- Phase: 2
- Setting: Single-arm, Phase II Trial of Trifluridine/Tipiracil (FTD-TPI), Bevacizumab, and Individualized Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer
- Sponsor: UMC Utrecht
- Enrolled: 40

## Sources

- ClinicalTrials.gov NCT06563986: https://clinicaltrials.gov/study/NCT06563986

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06563986.json