# A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

Source: https://onco.cc/trials/nct06564038/  
OnCo record `nct06564038` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of AZD0486, Prednisone, Rituximab in chronic lymphocytic leukaemia and mantle cell lymphoma, run by AstraZeneca, now recruiting.

## Summary

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies is a phase 1/2 interventional study registered as NCT06564038 by AstraZeneca, with 408 participants planned, started 2025-01-30 and due to reach its primary completion in 2029-06-11. Interventions recorded: Surovatamig, Prednisone (or equivalent), Rituximab, Cyclophosphamide, Vincristine. Conditions listed: Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle-cell Lymphoma, Large B-cell Lymphoma. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06564038
- Phase: 1/2
- Setting: A Phase I/II Open-Label Multi-Centre Master Protocol to Evaluate the Safety and Efficacy of AZD0486 Monotherapy or in Combination With Other Anticancer Agents in Participants With Mature B-Cell Malignancies
- Sponsor: AstraZeneca
- Enrolled: 408

## Sources

- ClinicalTrials.gov NCT06564038: https://clinicaltrials.gov/study/NCT06564038

## Connected records

- cancers: [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/), [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Mantle cell lymphoma](https://onco.cc/cancers/mantle-cell-lymphoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)
- drugs: [AZD0486](https://onco.cc/drugs/azd0486/), [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Prednisone](https://onco.cc/drugs/prednisone/), [Rituximab](https://onco.cc/drugs/rituximab/), [Vincristine](https://onco.cc/drugs/vincristine/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)

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JSON: https://onco.cc/api/v1/entities/nct06564038.json