# Cadonilimab (AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer

Source: https://onco.cc/trials/nct06566755/  
OnCo record `nct06566755` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of cadonilimab and bevacizumab (glioblastoma use) in colorectal cancer, run by Caigang Liu, now recruiting.

## Summary

Cadonilimab (AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer is a phase 3, interventional study registered as NCT06566755 by Caigang Liu, with a registry enrolment figure of 30 participants, started 2024-02-01 and due to reach its primary completion in 2026-02-01. Interventions recorded: Cadonilimab (AK104) combined with chemotherapy and bevacizumab. Conditions listed: Colorectal Cancer. Primary outcome: Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as Assessed by Investigator. Colorectal eligibility wording from the registry: "Recurrent or incurable metastatic colorectal adenocarcinoma confirmed by Histopathology". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06566755
- Phase: 3
- Setting: Study of Cadonilimab(AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer
- Sponsor: Caigang Liu
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT06566755: https://clinicaltrials.gov/study/NCT06566755

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Cadonilimab](https://onco.cc/drugs/cadonilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06566755.json