# Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC.

Source: https://onco.cc/trials/nct06574347/  
OnCo record `nct06574347` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Vebreltinib, Osimertinib in non-small-cell lung cancer and small-cell lung cancer, run by Avistone Biotechnology Co., Ltd., now recruiting.

## Summary

Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC. is a phase 2 interventional study registered as NCT06574347 by Avistone Biotechnology Co., Ltd., with 120 participants planned, started 2024-08-07 and due to reach its primary completion in 2026-10-31. Interventions recorded: Vebreltinib, Osimertinib, PLB1004. Conditions listed: Non-Small-Cell Lung Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06574347
- Phase: 2
- Setting: A Phase II Study of Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic Non-small Cell Lung Cancer.
- Sponsor: Avistone Biotechnology Co., Ltd.
- Enrolled: 120

## Sources

- ClinicalTrials.gov NCT06574347: https://clinicaltrials.gov/study/NCT06574347

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Osimertinib](https://onco.cc/drugs/osimertinib/), [Vebreltinib](https://onco.cc/drugs/vebreltinib/)
- companies: [Avistone Biotechnology](https://onco.cc/companies/avistone-biotechnology/)

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