# Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

Source: https://onco.cc/trials/nct06580002/  
OnCo record `nct06580002` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in pancreatic cancer, run by University of California, Irvine, now recruiting.

## Summary

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial is a phase 2, randomised interventional study registered as NCT06580002 by University of California, Irvine, with a registry enrolment figure of 75 participants, started 2024-12-02 and due to reach its primary completion in 2027-07. Interventions recorded: Riluzole; Placebo. Conditions listed: Breast Cancer; Sarcoma; Gastric Cancer; Lung Cancer; Head and Neck Cancer; Colorectal Cancer; Ovarian Cancer; Liver Cancer; Genitourinary Cancer; Gynecologic Cancer; Urinary Bladder Cancer; Leukemia; Lymphoid Leukemia; Myeloma Multiple; Prostate Cancer; Pancreas Cancer; Non-hodgkin Lymphoma; Hodgkin Lymphoma; Brain Cancer; Melanoma; Mycosis Fungoides; Kidney Cancer. Primary outcome: Change in circulating Brain-Derived Neurotrophic Factor (BDNF) levels over time in cancer survivors experiencing cognitive impairment (CRCI). Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06580002
- Phase: 2
- Setting: Repurposing Riluzole for Augmenting Brain-Derived Neuropathic Factor (BDNF) Levels and Cognitive Function in Patients Experiencing Cancer-Related Cognitive Impairment: An Interventional Pilot Clinical Trial
- Sponsor: University of California, Irvine
- Enrolled: 75

## Sources

- ClinicalTrials.gov NCT06580002: https://clinicaltrials.gov/study/NCT06580002

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06580002.json