# Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers

Source: https://onco.cc/trials/nct06580574/  
OnCo record `nct06580574` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Peking University, now recruiting.

## Summary

Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers is a phase 2, interventional study registered as NCT06580574 by Peking University, with a registry enrolment figure of 34 participants, started 2024-09-13 and due to reach its primary completion in 2029-06-01. Interventions recorded: PD1/PDL1 antibody monotherapy, up to 24 weeks; Intensive immunotherapy plus anti-VEGF treatment, up to 24 weeks; Radical surgery. Conditions listed: Gastric Cancer; Colon Cancer; MSI-H; DMMR Cancer. Primary outcome: Organ preservation rate. Colorectal eligibility wording from the registry: "* Histologically confirmed gastric cancer or colon cancer, without distant metastasis based on CR or MR". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06580574
- Phase: 2
- Setting: PD-1/PD-L1 Antibody With Selective Combination of Sintilimab, IBI310 and Lenvatinib Used for Organ Preservation in Non-metastatic Gastric or Colon Cancers With Mismatch Repair Deficiency or High Microsatellite Instability
- Sponsor: Peking University
- Enrolled: 34

## Sources

- ClinicalTrials.gov NCT06580574: https://clinicaltrials.gov/study/NCT06580574

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06580574.json