# Lvosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer

Source: https://onco.cc/trials/nct06593548/  
OnCo record `nct06593548` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivosidenib in colorectal cancer, run by Fudan University, not yet recruiting.

## Summary

Lvosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer is a phase 2, interventional study registered as NCT06593548 by Fudan University, with a registry enrolment figure of 36 participants, started 2024-11-01 and due to reach its primary completion in 2026-11-01. Interventions recorded: Ivosidenib (AK112). Conditions listed: CRC; MSS; Metastatic Cancer. Primary outcome: PFS. Colorectal eligibility wording from the registry: "* Initial diagnosis confirmed by colonoscopy and pathology as colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06593548
- Phase: 2
- Setting: A Prospective, Single-arm, Single-center, Phase II Clinical Study of Ivosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer: Efficacy and Safety Assessment
- Sponsor: Fudan University
- Enrolled: 36

## Sources

- ClinicalTrials.gov NCT06593548: https://clinicaltrials.gov/study/NCT06593548

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Ivosidenib](https://onco.cc/drugs/ivosidenib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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