# Node-Sparing Short-Course Radiation With CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: A Randomized, Prospective, Multicenter Study

Source: https://onco.cc/trials/nct06594692/  
OnCo record `nct06594692` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Sir Run Run Shaw Hospital, not yet recruiting.

## Summary

Node-Sparing Short-Course Radiation With CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: A Randomized, Prospective, Multicenter Study is a phase 2, randomised interventional study registered as NCT06594692 by Sir Run Run Shaw Hospital, with a registry enrolment figure of 140 participants, started 2024-10 and due to reach its primary completion in 2025-09-30. Interventions recorded: Node-Sparing Short-Course Radiotherapy Combined with CAPOX and Sintilimab; CAPOX Chemotherapy. Conditions listed: Microsatellite Stable (MSS) Colon Cancer; Locally Advanced Colon Cancer. Primary outcome: pathological complete response rate. Colorectal eligibility wording from the registry: "Tumor confirmed by colonoscopy and enhanced abdominal CT to be ≥ 12 cm from the anal verge". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: mRCAT-C
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06594692
- Phase: 2
- Setting: Node-sparing Modified Short-Course Radiation Combined With CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer : A Randomized, Prospective, Multicenter, Open-label Clinical Trial
- Sponsor: Sir Run Run Shaw Hospital
- Enrolled: 140

## Sources

- ClinicalTrials.gov NCT06594692: https://clinicaltrials.gov/study/NCT06594692

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06594692.json