# Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatme

Source: https://onco.cc/trials/nct06607458/  
OnCo record `nct06607458` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Melphalan, Bevacizumab in colorectal cancer, run by Delcath Systems Inc., now recruiting.

## Summary

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease is a phase 2 interventional study registered as NCT06607458 by Delcath Systems Inc., with 90 participants planned, started 2025-08-05 and due to reach its primary completion in 2026-12. Interventions recorded: Melphalan/HDS Followed by Consolidation Treatment with Trifluridine-tipiracil plus Bevacizumab, Trifluridine-tipiracil plus Bevacizumab Alone. Conditions listed: Refractory Metastatic Colorectal Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06607458
- Phase: 2
- Setting: An Open-label, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of Induction Treatment With Melphalan/HDS Followed by Consolidation Treatment With Trifluridine-Tipiracil Plus Bevacizumab Versus Trifluridine-Tipiracil Plus Bevacizumab Alone in Patients With Refractory Metastatic Colorectal Cancer With Liver Dominant Disease
- Sponsor: Delcath Systems Inc.
- Enrolled: 90

## Sources

- ClinicalTrials.gov NCT06607458: https://clinicaltrials.gov/study/NCT06607458

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- drugs: [Bevacizumab](https://onco.cc/drugs/bevacizumab/), [Melphalan (including hepatic delivery system)](https://onco.cc/drugs/melphalan/)
- companies: [Delcath Systems](https://onco.cc/companies/delcath/)

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