# A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway

Source: https://onco.cc/trials/nct06614751/  
OnCo record `nct06614751` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1 trial of DAT-2645 run by Danatlas Pharmaceuticals Co., Ltd, not yet recruiting.

## Summary

A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway is a phase 1 interventional study registered as NCT06614751 by Danatlas Pharmaceuticals Co., Ltd, with 112 participants planned, started 2024-11-01. Conditions recorded: Solid Cancers, BRCA Mutation, HRD Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer, Pancreatic Cancer, Endometrial Cancer, Gastric Cancer, Advanced Cancer and Metastatic Solid Tumors. Interventions recorded: DAT-2645 tablet and DAT-2645 tablet.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Registry id: NCT06614751
- Phase: 1
- Setting: A Phase I, Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of DAT-2645 in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DNA Damage Repair Pathway
- Sponsor: Danatlas Pharmaceuticals Co., Ltd
- Enrolled: 112

## Sources

- ClinicalTrials.gov NCT06614751: https://clinicaltrials.gov/study/NCT06614751

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Prostate cancer](https://onco.cc/cancers/prostate/)
- drugs: [DAT-2645](https://onco.cc/drugs/dat-2645/)
- companies: [Danatlas Pharmaceuticals](https://onco.cc/companies/danatlas-pharmaceuticals/)

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JSON: https://onco.cc/api/v1/entities/nct06614751.json