# Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC

Source: https://onco.cc/trials/nct06623656/  
OnCo record `nct06623656` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cemiplimab in lung cancer, run by Weill Medical College of Cornell University, now recruiting.

## Summary

Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC is a phase 2, randomised interventional study registered as NCT06623656 by Weill Medical College of Cornell University, with a registry enrolment figure of 112 participants, started 2025-02-21 and due to reach its primary completion in 2026-12. Interventions recorded: Cemiplimab; Platinum based chemotherapy; Stereotactic body radiation therapy. Conditions listed: Carcinoma, Non-Small-Cell Lung. Primary outcome: Number of participants with pathological complete response (pCR). Lung eligibility wording from the registry: "Patients with histologically or cytologically proven clinical stages IB (T2aN0), II, and III(N2) NSCLC (according to AJCC version 9) eligible for surgical resection with curative intent". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06623656
- Phase: 2
- Setting: Multicenter Randomized Phase II Trial of Neoadjuvant Radioimmunotherapy Versus Chemoimmunotherapy in Patients With Clinical Stages IB-III (N2) Non-small Cell Lung Cancer
- Sponsor: Weill Medical College of Cornell University
- Enrolled: 112

## Sources

- ClinicalTrials.gov NCT06623656: https://clinicaltrials.gov/study/NCT06623656

## Connected records

- cancers: [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Cemiplimab](https://onco.cc/drugs/cemiplimab/)
- companies: [Regeneron](https://onco.cc/companies/regeneron/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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