# Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation

Source: https://onco.cc/trials/nct06634056/  
OnCo record `nct06634056` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in lung cancer, run by University Health Network, Toronto, now recruiting.

## Summary

Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation is a phase 2, randomised interventional study registered as NCT06634056 by University Health Network, Toronto, with a registry enrolment figure of 150 participants, started 2026-06-15 and due to reach its primary completion in 2031-11-30. Interventions recorded: Pentoxifylline; Placebo; α-Tocopherol. Conditions listed: Non-Small Cell Lung Cancer; Radiation Induced Lung Injury (RILI). Primary outcome: Change in risk of Lung Injury. Lung eligibility wording from the registry: "* Histologically confirmed diagnosis of stage III NSCLC, planned for treatment with concurrent chemoradiation and consolidation immune checkpoint inhibitor as per standard of care with no medical contraindications to therapy". Sites: Canada. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: P4-PACIFIC
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT06634056
- Phase: 2
- Setting: Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol in Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation
- Sponsor: University Health Network, Toronto
- Enrolled: 150

## Sources

- ClinicalTrials.gov NCT06634056: https://clinicaltrials.gov/study/NCT06634056

## Connected records

- cancers: [Unresectable stage III non-small-cell lung cancer](https://onco.cc/cancers/stage-iii-unresectable-nsclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06634056.json